Stapeliinae is a subtribe of flowering plants within the tribe Ceropegieae of the subfamily Asclepiadoideae of the family Apocynaceae. The subtribe comprises about 35 genera, including both the stem-succulent "stapeliads" and the horticulturally popular genera Brachystelma and Ceropegia. The largest number of genera are native to Africa, but a more limited number of genera are widespread in Arabia and Asia. Historically, a similarly circumscribed taxon was treated as a separate tribe, Stapelieae.

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