Senecioneae is the largest tribe of the Asteraceae, or the sunflower family, comprising over 150 genera and over 3,500 species. Almost one-third of the species in this tribe are placed in the genus Senecio. Its members exhibit probably the widest possible range of form to be found in the entire plant kingdom, and include annuals, minute creeping alpines, herbaceous and evergreen perennials, shrubs, climbers, succulents, trees, and semi-aquatic plants.

Plants in this tribe are responsible for more livestock poisonings than all other plants combined. Its members usually contain liver and kidney toxic and carcinogenic unsaturated pyrrolizidine alkaloids in Senecio and furanoeremophilanes in Tetradymia.

A number of species are well known in horticulture.

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