Ambrosia grayi, the woollyleaf bur ragweed, is a North American species of plants in the family Asteraceae. It is native to the west-central part of the Great Plains of the United States, in the states of Nebraska, Kansas, Colorado, New Mexico, Oklahoma, and Texas.

Ambrosia grayi is a perennial herb up to 30 cm (12 inches) tall. Leaves are elliptical or egg-shaped. Flower heads are small and inconspicuous, as the plant is wind-pollinated. The heads develop into spiny burs as the seeds ripen.

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