Amphipyrinae is a subfamily of owlet moths in the family Noctuidae. There are more than 50 genera and 210 described species in Amphipyrinae, although the classifications are likely to change over time.

This subfamily has been used as a catchall for members of Noctuidae that don't fit well into other subfamilies. As such, many of its members lack morphological traits that would allow assignment into one of the other subfamilies. Genetic analysis conducted on Amphipyrinae is improving the classification of these genera.

In 2021, phylogenetic research resulted in 11 genera being transferred from Amphipyrinae to six different subfamilies, and it is expected that more members of Amphipyrinae will be reassigned as further research is done.

Psaphidini is included here as a tribe, but is sometimes treated as the subfamily Psaphidinae. The Australian genera in Acronictinae are sometimes considered part of Amphipyrinae.

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