Anolis apletophallus is a species of anoles, iguanian lizards in the family Dactyloidae native to Panama. The species was split from Anolis limifrons in Köhler and Sunyer (2008). It has been reported in Panama, Honduras and Colombia. A decline in its population in Panama over a 40-year timespan has been attributed to changes in local climate, with years following El Niño negatively affecting the species.

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