Aphantophryne sabini is a species of frog in the family Microhylidae. It is endemic to Papua New Guinea and is only known from the region of its type locality, Myola Guest House in the Owen Stanley Range, Northern Province. The specific name sabini honors Andrew E. Sabin, an American businessman, philanthropist, and environmentalist who joined the expedition during which the holotype of this species was collected. However, its vernacular name Guest House Guinea frog refers to the type locality instead.

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