Apocynoideae is a subfamily of the flowering plant family Apocynaceae (order Gentianales), also called the 'dogbane' or milkweed family, containing about 860 species across 78 genera. Several are of pharmacological interest; Strophanthus has furnished highly effective arrow poisons, due to their cardiac glycoside content. Apocynoideae also includes many popular landscaping and ornamental species, one of the best-known, and most infamous, being the oleander (Nerium oleander); the subfamily also contains remarkable pachycaul genera like Adenium and Pachypodium.

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