Appalachia is a socioeconomic region associated with the Appalachian Mountains in the eastern United States.

Appalachia may also refer to:

• Appalachian (disambiguation)
• Appalachia (Mesozoic), a Mesozoic-era island
• Appalachia, Virginia, a town in the U.S. state of Virginia
• Appalachia, a rhapsody by Frederick Delius
• Appalachia (journal), a mountaineering and conservation journal published by the Appalachian Mountain Club since 1894
• Appalachia (grasshopper), a genus of grasshopper from eastern North America

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