Aspergillus quadrilineatus is a species of fungus in the genus Aspergillus. It is from the Nidulantes section. The species was first described in 1939. It has been isolated from soil in New Jersey, Egypt, Spain, China, and Namibia. It has been reported to produce asperthecin, averufin, 7-methoxyaverufin, sterigmatocystin, versicolourin, desferritriacetylfusigen, echinocandin B & E, variacoxanthone B, emestrin, aurantioemestrin, dethiosecoemestrin, emindol DA, microperfuranone, penicillin G, quadrilineatin, and sterigmatocystin.

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