Atropa is a genus of flowering plants in the nightshade family, Solanaceae: tall, calcicole, herbaceous perennials (rhizomatous hemicryptophytes), bearing large leaves and glossy berries particularly dangerous to children, due to their combination of an attractive, cherry-like appearance with a high toxicity. Atropa species favour temperate climates and alkaline soils, often growing in light shade in woodland environments associated with limestone hills and mountains. Their seeds can remain viable in the soil for long periods, germinating when the soil of sites in which plants once grew (but from which plants have long been absent) is disturbed by human activity or by natural causes, e.g. the windthrow of trees (a property shared by the seeds of other Solanaceae in tribe Hyoscyameae e.g. those of Hyoscyamus spp., the henbanes). The best-known member of the genus Atropa is deadly nightshade (A. belladonna) – the poisonous plant par excellence in the minds of many. The pharmacologically active ingredients of Atropa species include atropine, scopolamine, and hyoscyamine, all tropane alkaloids having anticholinergic, deliriant, antispasmodic and mydriatic properties. The genus is named for Άτροπος (Atropos) – lit. 'she who may not be turned (aside)' – one of the Three Fates and cutter of the thread of life / bringer of death – in reference to the extreme toxicity of A.belladonna and its fellow species – of which four others are currently accepted.

In some older classifications, the mandrake (Mandragora officinarum) has been placed in the genus Atropa, under the binomial Atropa mandragora.

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