Buddleja marrubiifolia, commonly known as the woolly butterflybush, is a perennial shrub which is endemic to the Chihuahuan Desert from southern Texas to San Luis Potosí in Mexico, where it grows on limestone and gypsum soils in canyons and arroyos at elevations of 600 to 2,250 m (1,970 to 7,380 ft) elevation. The species was first named and described by George Bentham in 1846.

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