Callyspongia siphonella, commonly known as colonial tube-sponge, is a species of sea sponge endemic to the Red Sea. Clusters of its pale lavender to pink long tubes reach up to 60 centimetres (24 in) in size. Callyspongia siphonella contains a bioactive compound, Sipholenol A., that has been studied for its anti-proliferative properties in human breast cancer; these properties provide promise in its potential for developing future compounds and thus contributes greatly to future cancer research.

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