Calymene is a genus of trilobites in the order Phacopida, suborder Calymenina, that are found throughout North America, North Africa, and Europe in primarily Silurian outcrops. Calymene is closely related to Flexicalymene, and both genera are frequently found enrolled. Calymene trilobites are small, typically 2 cm in length. The cephalon is the widest part of the animal and the thorax usually has 13 segments.

The correct genus authorship is Brongniart (1822). A previously published genus description in Desmarest (1816) (often mis-cited as "Calymena" Desmarest, 1817) was suppressed by ICZN Opinion 1433.

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