The Mexican wolf (Canis lupus baileyi), also known as the lobo mexicano (or, simply, lobo) is a subspecies of gray wolf (C. lupus) native to eastern and southeastern Arizona and western and southern New Mexico (in the United States) and fragmented areas of northern Mexico. Historically, the subspecies ranged from Southern California south into Baja California, east through the Sonora and Chihuahua Deserts and into West Texas.

Its ancestors were likely among the first gray wolves to enter North America after the extinction of the Beringian wolf, as indicated by its southern range and basal physical and genetic characteristics. Though once held in high regard in Pre-Columbian Mexico, Canis lupus baileyi became the most endangered gray wolf subspecies in North America, having been extirpated in the wild during the mid-1900s through a combination of hunting, trapping, poisoning and the removal of pups from dens, mainly out of fear, by livestock herders and ranch owners. After being listed officially under the Endangered Species Act in 1976, both the United States and Mexico collaborated to capture all lobos remaining in the wild. This extreme preventative measure would end up forestalling their imminent extinction; five wild Mexican wolves (four males and one pregnant female) were captured, alive, in Mexico between 1977 and 1980. Once settled in captive rescue centers, this group of wolves would prove vital in starting a captive breeding program. Thanks to these preemptive measures, captive-bred Mexican wolves were released into recovery areas in Arizona and New Mexico beginning in 1998 in an effort to recolonize the animals' historical range.

As of 2025, there are at least 286 wild Mexican wolves in the US and 45 in Mexico, and 380 in captive breeding programs, up from the 11 individuals that were released in Arizona in 1998. These numbers represent a minimum as the survey only counts wolf sightings confirmed by Interagency Field Team staff.

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