Canthigaster leoparda, known as the leopard sharpnose puffer, is a species of pufferfish in the family Tetraodontidae. It is native to the Indo-Pacific, ranging from Christmas Island to the Philippines, Ambon, and Guam. It occurs at a depth range of 30 to 50 m (98 to 164 ft), and it is usually found in the vicinity of drop-offs and caves. It reaches 7.5 cm (3 inches) SL and is often seen either alone or in pairs. The species is known to be oviparous.

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