The crocodile icefish or white-blooded fish comprise a family (Channichthyidae) of notothenioid fish found in the Southern Ocean around Antarctica. They are the only known vertebrates to lack hemoglobin in their blood as adults. Icefish populations are known to reside in the Atlantic and Indian sectors of the Southern Ocean, as well as the continental shelf waters surrounding Antarctica. Water temperatures in these regions remain relatively stable, generally ranging from −1.8 to 2 °C (28.8 to 35.6 °F). One icefish, Champsocephalus esox, is distributed north of the Antarctic Polar Frontal Zone. At least 16 species of crocodile icefish are currently recognized, although eight additional species have been proposed for the icefish genus Channichthys.

In February 2021, scientists discovered and documented a breeding colony of Neopagetopsis ionah icefish estimated to have 60 million active nests across an area of approximately 92 square miles at the bottom of the Weddell Sea in Antarctica. The majority of nests were occupied by one adult fish guarding an average of 1,735 eggs in each nest.

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