Cirsium neomexicanum is a North American species of thistle known by the common names New Mexico thistle, powderpuff thistle, lavender thistle, foss thistle and desert thistle.

This plant is native to the southwestern United States and northwestern Mexico, particularly the Mojave and Sonoran Deserts. It has been found in California, Nevada, Arizona, Sonora, Utah, Colorado, New Mexico, and Texas.

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