Cissus cornifolia is a species of flowering plant in the Vitaceae family. It is an erect or semi-scandent woody shrub up to 3 meters in height, and found from sub-Saharan Africa and Tropical Africa south to Botswana, Mozambique and South Africa. It is one of more than 300 species forming the genus Cissus.

Growing from a large tuberous rootstock and found up to 2000m, in open woodland and grassland, often on granite outcrops, it occasionally develops tendrils. Branch nodes are conspicuously swollen and new parts of the plant have a ferruginous, floccose covering, persisting on the bracts.

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