Cladonia perforata is a rare species of lichen known as Florida perforate cladonia and Florida perforate reindeer lichen. It is endemic to the state of Florida in the United States, where it is known from 16 populations in four widely separated areas of the state. It is native to a very specific type of Florida scrub habitat which is increasingly rare and patchy due to habitat destruction, degradation, and fragmentation. In 1993 this was the first species of lichen to be federally listed as an endangered species of the United States.

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