The Cleomaceae are a small family of flowering plants in the order Brassicales, comprising about 220 species in three genera, Cleome, Cleomella, and Polanisia. These genera were previously included in the family Capparaceae, but were raised to a distinct family when DNA evidence suggested the genera included in it are more closely related to the Brassicaceae than they are to the Capparaceae. The APG II system allows for Cleomaceae to be included in Brassicaceae. Cleomaceae includes C₃, C₃–C₄, and C₄ photosynthesis species.

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