Diphylleidae (also Collodictyonidae) is a group of aquatic, unicellular eukaryotic organisms with two to four terminal flagella. They feed by phagocytosis, ingesting other unicellular organisms like algae and bacteria. It is the sister group of Sulcomonadidae.

Recent molecular analyses place collodictyonids (e.g. Collodictyon) in a clade also containing Rigifilida and Mantamonadidae. This clade has been named CRuMs and is sister to Amorphea.

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