Cophylinae is a subfamily of microhylid frogs endemic to Madagascar. It has over 100 species in eight genera. Members of this subfamily range from minute (< 10 mm adult body size) to fairly large (> 100 mm adult body size), and they are highly ecologically diverse. DNA barcode research has revealed a significant taxonomic gap in this subfamily, and an estimated 70+ candidate species were identified. Many of these have subsequently been described, as well as numerous new discoveries (e.g. 26 species of Stumpffia described in 2017).

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