Anacis major (synonym Coreopsis major) is a North American species of tickseeds, in the family Asteraceae. It is native to the eastern United States, from Louisiana to Virginia and as far inland as Indiana and Ohio. There are isolated populations in Pennsylvania, Long Island, and Massachusetts, most likely escapes from cultivation.

Anacis major is a perennial herb up to 90 cm (3 feet) tall with yellow flower heads.

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