Craugastor omoaensis, known commonly as the Sierra de Omoa streamside frog, is a presumed extinct species of frog in the family Craugastoridae. It is endemic to Honduras and also is one of 13 species of amphibians and reptiles that are endemic to the Sierra de Omoa. It is known from only 24 specimens studied. Its natural habitats are subtropical or tropical moist montane forests, rivers, and intermittent rivers. The Sierra de Omoa streamside frog was last seen in 1974. All subsequent expeditions seeking the frog have failed to locate any individuals, and it is presumed to have gone extinct.

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