The Santa Catalina rattlesnake (Crotalus catalinensis) is a species of pit viper endemic to Isla Santa Catalina in the Gulf of California just off the east coast of the state of Baja California Sur, Mexico. Like all other pit vipers, it is venomous. No subspecies are currently recognized. A relatively small and slender species, its most distinctive characteristic is that it lacks a rattle. They are also a generally nocturnal species. Though the species is classified as Critically Endangered on the IUCN Red List, there are few efforts for the snake's conservation.

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