The Cuban rock iguana (Cyclura nubila), also known as the Cuban ground iguana or Cuban iguana, is a species of lizard of the iguana family. It is the second largest of the West Indian rock iguanas (genus Cyclura), one of the most endangered groups of lizards. A herbivorous species with a thick tail and spiked jowls, it is one of the largest lizards in the Caribbean.

The Cuban iguana is distributed throughout the mainland of Cuba and its surrounding islets with a feral population thriving on Isla Magueyes, Puerto Rico. A subspecies is found on the Cayman Islands of Little Cayman and Cayman Brac. Females guard their nest sites and one population nests in sites excavated by Cuban crocodiles. As a defence measure, the Cuban iguana often makes its home within or near prickly-pear cacti.

The numbers of iguanas have been bolstered as a result of captive-breeding and other conservation programs. C. nubila has been used to study evolution and animal communication, and its captive-breeding program has been a model for other endangered lizards in the Caribbean.

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