The Mezquital pupfish (Cyprinodon meeki) is a species of pupfish in the family Cyprinodontidae. It is endemic to Durango in Mexico. This species was described by Robert Rush Miller in 1976 from a pond which was fed by hot springs within the basin of the Río del Tunal, approximately 9 kilometres (5.6 mi) east of Durango City at an altitude of about 1,880 metres (6,170 ft). The specific name honors the American ichthyologist Seth Eugene Meek (1859-1914), a pioneer of the study of the freshwater fish of Mexico.

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