The Depressariinae – sometimes spelled "Depressiinae" in error – are a subfamily of moths in the superfamily Gelechioidea. Like their relatives therein, their exact relationships are not yet very well resolved. It has been considered part of family Elachistidae sensu lato or included in an expanded Oecophoridae. In modern classifications they are treated as the distinct gelechioid family Depressariidae.

As regards subdivisions, the Amphisbatinae are often held to be as close to the Depressariinae as to be included there, in particular if the latter are raised to full family rank, but also otherwise (as a tribe Amphisbatini in the Depressariinae). If Depressariinae are treated as oecophorid subfamily, it is more common to include the group around Cryptolechia, which is sometimes (especially in older arrangements) separated as tribe Cryptolechiini in subfamily Cryptolechiinae. The lineage of Cacochroa and its closest relatives – typically included in the "Cryptolechiinae" if these are treated as independent oecophorid subfamily – actually seems to be closer to Orophia, and would be part of tribe Orophiini if these are placed in the Oecophorinae. But they have also been included in the present group (as tribe(s) Orophiini and sometimes also Cacochroini), particularly if this is considered a full-fledged family. The same holds true for the Xyloryctidae, a group treated here as family but previously thought to be a subfamily of the Oecophoridae. Finally, the Semioscopis lineage is occasionally separated from the rest of the Depressariinae as tribe Epigraphiini (after its junior synonym Epigraphia). In all such treatments, the core group of Depressariinae becomes a tribe Depressariini.

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