Drosophila neoclavisetae is an endangered species of fly from Hawaii, in the species rich lineage of Hawaiian Drosophilidae. It is only found in West Maui. It can be distinguished from its East Maui counterpart, D. clavisetae, by the shape of the long hairs on the abdomen, which are more rounded in D. neoclavisetae and more flattened in D. clavisetae.

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