Empyreuma pugione, the spotted oleander caterpillar moth, is a moth of the subfamily Arctiinae. It is found in the West Indies, where it has been collected at elevations up to 733m, but has been introduced to the US state of Florida.

The wingspan is 43–48 mm. They fly during the day.

The larvae feed on Nerium oleander, but are likely to have fed on a Caribbean species from a New World Apocynaceae genus such as Thevetia, Plumeria, Mandevilla, or Tabernaemontana prior to the introduction of oleander. They are light orange and hairy.

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