Erythroxylum macrophyllum is a tropical tree in the family Erythroxylaceae. It is found in Costa Rica. It grows at altitudes of 1200–1400 m. It is a small tree of the understory reaching 2 to 6 meters. The leaves are alternate and are aligned in a plane. Small white flowers are borne March through June; they are followed by fruit that persist until September and are red when ripe.

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