The Andes giant glass frog (Espadarana andina) is a species of frog in the family Centrolenidae. It is found in the Cordillera Oriental of Colombia and the Mérida Andes and Serranía del Perijá of Venezuela.

Its natural habitats are cloud forests and montane evergreen dry forests. It lives along mountain streams and lays its eggs on vegetation over the streams. It is not considered threatened by the IUCN.

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