Hesperocnide sandwicensis, the Hawai'i stingingnettle, is a rare species of nettle endemic to the island of Hawai'i. Less than 1000 plants from only 3 occurrences are estimated to exist due to grazing pressure from invasive sheep, goats, and pigs.

The closest relative of H. sandwicensis, and the only other species in the genus Hesperocnide, is the California endemic Hesperocnide tenella.

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