The manchineel tree (Hippomane mancinella) is a species of flowering plant in the spurge family (Euphorbiaceae). Its native range stretches from tropical southern North America to northern South America.

The name manchineel (sometimes spelled manchioneel or manchineal), as well as the specific epithet mancinella, are from Spanish manzanilla ('little apple'), from the superficial resemblance of its fruit and leaves to those of an apple tree. It is also called beach apple.

A present-day Spanish name is manzanilla de la muerte, 'little apple of death'. This refers to the fact that manchineel is one of the most toxic trees in the world: it has milky-white sap that contains numerous toxins and can cause blistering. The sap is present in every part of the tree—bark, leaves, and fruit.

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