Hyloxalus mittermeieri is a species of frogs in the family Dendrobatidae. It is endemic to Peru and only known from the area of its type locality on the eastern slopes of the central Andes in the San Martín Region. Its natural habitats are tropical montane forests near streams. It is only known from two specimens, from 1,620 and 2,050 m (5,310 and 6,730 ft) asl on the road between Rioja and Balzapata.

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