Lonomia obliqua is a species of saturniid moth ("giant silk moth") from South America. It is famous for its larval form, rather than the adult moth, primarily because of the caterpillar's defense mechanism, urticating bristles that inject a potentially deadly venom. The caterpillar has been responsible for many human deaths, especially in southern Brazil. Its venom has been the subject of numerous medical studies. The species was first described by Francis Walker in 1855. Guinness World Records classified Lonomia obliqua as the most venomous caterpillar in the world.

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