Lophophora diffusa, commonly known as false peyote, is a species of plant in the family Cactaceae and one of the species in the Lophophora genus. It is endemic to Mexico in the outskirts of Querétaro. This species contains only trace amounts of the psychedelic alkaloid mescaline. Instead, the sedative pellotine is the principal alkaloid. The species name diffusa refers to the flat tubercles that are outspread without the plant having prominent ribs.

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