Lophospermum is a genus of herbaceous perennial climbers or scramblers, native to mountainous regions of Mexico and Guatemala. Those that climb use twining leaf stalks. Their flowers are tubular, in shades of red, violet and purple, the larger flowers being pollinated by hummingbirds. Now placed in the greatly expanded family Plantaginaceae, the genus was traditionally placed in the Scrophulariaceae. The close relationship with some other genera, particularly Maurandya and Rhodochiton, has led to confusion over the names of some species.

Lophospermum erubescens and Lophospermum scandens are cultivated as ornamental plants, as climbers or trailers. Various Lophospermum cultivars are grown, often under trade names such as "Lofos®".

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