Lysimachia asperulifolia (orth. var. L. asperulaefolia) is a rare species of flowering plant in the Primulaceae known by the common name rough-leaved loosestrife and roughleaf yellow loosestrife. It is endemic to the Atlantic coastal plain in North Carolina and northern South Carolina in the United States, where there are 64 known populations. It is a federally listed endangered species of the United States.

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