Maclura is a genus of flowering plants in the mulberry family, Moraceae. It includes the inedible Osage orange, which is used as mosquito repellent and grown throughout the United States as a hedging plant. It is dioecious, with male and female flowers borne on separate plants.

Maclura is closely related to the genus Cudrania, and hybrids between the two genera have been produced. Some botanists recognize a more broadly defined Maclura that includes species previously included in Cudrania and other genera of Moraceae. The genus likely originated in South America during the Paleogene.

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