Manduca neglecta is a moth of the family Sphingidae. It is known from eastern Ecuador, Peru and Bolivia.

The wingspan is 99–114 millimetres (3.9–4.5 in) for males and 106–118 millimetres (4.2–4.6 in) for females. It is similar to Manduca schausi. Adults have been recorded in January, from April to May, July to August and November to December in Ecuador. In Bolivia, it has been recorded in November.

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