Marah macrocarpa is a species of plant in the genus Marah commonly referred to as chilicothe, wild cucumber, manroot or bigroot. It is a perennial herb with a large tuber native to Southern California and northern Baja California. It grows in a diverse number of habitats in coastal and inland regions. A member of the gourd family, it produces a large, green, prickly fruit. Indigenous peoples traditionally used it for treating hair loss and pain relief. All parts of the plant are toxic, as it contains cucurbitacins and ribosome-inactivating proteins.

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