Megastomatohyla is a genus of frogs in the family Hylidae. They are endemic to the cloud forests of central Veracruz and Oaxaca, Mexico. All are rare species with restricted distributions. The generic name is derived from Greek mega (="large") and stem of the genitive stomatos (="mouth"), referring to the enlarged oral disc of the tadpoles, juxtaposed with Hyla, the genus in which the four Megastomatohyla species were previously placed. Common name large-mouthed treefrogs has been coined for this genus.

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