Metachroma is a genus of leaf beetles in the subfamily Eumolpinae. It is distributed from Ontario, Canada to Mendoza, Argentina, including the Antilles (where a large number of species occur). It has also been suggested that the genus extends to the Pacific Islands, though this is not confirmed. There are about 140 described species in Metachroma, 40 of which are found north of Mexico. An extinct species is also known from the Eocene of the United States.

The name of the genus comes from the Ancient Greek μετα ("different") and χρῶμα ("color"), referring to the variations in color pattern found within many of the species.

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