Microsynodontis is a genus of upside-down catfishes native to freshwater rivers in western Africa. The genus was originally described by British-Belgian zoologist George Albert Boulenger in 1903 based upon the type species Microsynodontis batesii. The name microsynodontis comes from the Greek word mikro, meaning small, and the Greek term synodon, meaning "with the teeth all growing together".

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