Nymphargus grandisonae (common names: giant glass frog, red-spotted glassfrog) is a species of frog in the family Centrolenidae. It is found in Andes of Colombia and Ecuador. Its natural habitat is tropical moist montane forest (cloud forest); larvae develop in streams and still-water pools. Its habitat is threatened by habitat loss, introduced fish, and agricultural pollution, but it is still a common species not considered threatened by the IUCN.

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