Ophiotrichidae are a family of brittle stars within the suborder Gnathophiurina.

All of its species have arms with delicate, translucent, thorny spines. Their arms are flexible in all directions. Their jaws contain clusters of well-developed tooth papillae on the apex but not on the sides. There are no mouth papillae. Inside the mouth edge there is a second pair of tube feet. They show large radial shields. The dorsal surface of the disc is covered with spines and thorny towers.

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