Pachydactylus is a genus of insectivorous geckos, lizards in the family Gekkonidae. The genus is endemic to Africa, and member species are commonly known as thick-toed geckos. The genus also displays rich speciation, having 58 distinct species identified when compared to other closely related gecko genera like Rhoptropus, most of which have emerged since 35 Ma. It has been suggested that the reason for this rich speciation is not from adaptive radiation nor nonadaptive radiation, but that the genus represents a clade somewhere between the two drivers of speciation. P. bibronii geckos have been used by NASA as animal models for experimentation.

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