Platynota is a polyphyletic group of anguimorph lizards and thus belongs to the order Squamata of the class Reptilia. Since it was named in 1839, it has included several groups, including monitor lizards, snakes, mosasaurs, and helodermatids. Its taxonomic use still varies, as it is sometimes considered equivalent to the group Varanoidea and other times viewed as a distinct group. It is phylogenetically defined as a clade containing Varanidae (the monitor lizards). It also includes many extinct species.

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