Plesiocystiscinae is a subfamily of minute sea predatory sea snails, marine gastropod mollusks or micromollusks in the infraorder Neogastropoda.

The genus name on which this subfamily name is based is derived from the Greekword plesios, near, in the sense of plesiomorphic, in other words having characters close to those of the ancestor, combined with Cystiscus the name of a closely related genus.

Sometimes the single genus in this subfamily is simply left in the larger family Marginellidae.

(Note: Gastropod taxonomy has been in flux for more than half a century, and this is especially true currently, because of new research in molecular phylogeny. Because of all the ongoing changes, different reliable sources can yield very different classifications.)

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